AustralieFrV1, Main, Exploration, bibRecord, 009532

Imatinib does not induce cardiac left ventricular failure in gastrointestinal stromal tumours patients : Analyis of EORTC-ISG-AGITG study 62005

Identifieur interne : 009532 ( Main/Exploration ); précédent : 009531; suivant : 009533

Imatinib does not induce cardiac left ventricular failure in gastrointestinal stromal tumours patients : Analyis of EORTC-ISG-AGITG study 62005

Auteurs : Jaap Verweij [Pays-Bas] ; Paolo G. Casali [Italie] ; Dusan Kotasek [Australie] ; Axel Le Cesne [France] ; Peter Reichard [Allemagne] ; Ian R. Judson [Royaume-Uni] ; R. Issels [Allemagne] ; Allan T. Van Oosterom [Belgique] ; Martine Van Glabbeke [Belgique] ; Jean-Yves Blay [France]

Source :

European journal of cancer : (1990) [ 0959-8049 ] ; 2007.

RBID : Pascal:07-0209379

Descripteurs français

Pascal (Inist)
- Imatinib, Protein-tyrosine kinase, Inhibiteur enzyme, Insuffisance cardiaque, Homme, Cancérologie, Insuffisance ventriculaire gauche, Pharmacologie, Anticancéreux, Ventricule cardiaque, Tumeur stromale gastrointestinale, EORTC.
Wicri :
- topic : Homme, Pharmacologie.

English descriptors

KwdEn :
- Antineoplastic agent, Cancerology, Enzyme inhibitor, European Organization for Research and Treatment of Cancer, Gastrointestinal stromal tumor, Heart failure, Heart ventricle, Human, Imatinib, Left ventricular failure, Pharmacology, Protein-tyrosine kinase.

Abstract

Recent publications have suggested that imatinib (Glivec) may be cardiotoxic. We have therefore assessed the largest study on the agent performed in patients with gastrointestinal stromal tumours, randomising a daily dose of 400 mg versus 800 mg. 946 Patients were entered, 942 patients received at least one dose of imatinib. The median time on treatment was 24 months. A total of 24,574 exposure months could be analysed. We could not identify an excess of cardiac events in the study population. In 2 patients (0.2%) a possible cardiotoxic effect of imatinib could not fully be excluded. The current analysis of a large randomised prospective study could not confirm previous suggestions of imatinib induced cardiac toxicity.

Affiliations:

Links toward previous steps (curation, corpus...)

to stream PascalFrancis, to step Corpus: 003C79
to stream PascalFrancis, to step Curation: 002409
to stream PascalFrancis, to step Checkpoint: 003839
to stream Main, to step Merge: 009F51
to stream Main, to step Curation: 009532

Le document en format XML

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<front><div type="abstract" xml:lang="en">Recent publications have suggested that imatinib (Glivec) may be cardiotoxic. We have therefore assessed the largest study on the agent performed in patients with gastrointestinal stromal tumours, randomising a daily dose of 400 mg versus 800 mg. 946 Patients were entered, 942 patients received at least one dose of imatinib. The median time on treatment was 24 months. A total of 24,574 exposure months could be analysed. We could not identify an excess of cardiac events in the study population. In 2 patients (0.2%) a possible cardiotoxic effect of imatinib could not fully be excluded. The current analysis of a large randomised prospective study could not confirm previous suggestions of imatinib induced cardiac toxicity.</div>
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Imatinib does not induce cardiac left ventricular failure in gastrointestinal stromal tumours patients : Analyis of EORTC-ISG-AGITG study 62005

Imatinib does not induce cardiac left ventricular failure in gastrointestinal stromal tumours patients : Analyis of EORTC-ISG-AGITG study 62005

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Descripteurs français

English descriptors

Abstract

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